Carrageenan as a Food Additive

If you look towards the back of the ingredients list on many processed foods you’ll frequently see an ingredient called carrageenan. Like lots of other confusing sounding food-stuffs, most people blithely consume it daily without a scintilla of awareness about what it actually is or whether or not it’s good for you.

Overall carrageenan is (mostly) harmless, but it has a variety of troublesome side effects that shouldn’t go unnoticed, most notably high correlations to colon cancer, inflammation, and a depressed immune system.

What Is Carrageenan?

Carrageenan is a polysaccharide that’s derived from red seaweed. On a molecular level it’s actually very similar to plastic and is popular for that reason. It bends easily but snaps back into place, which makes it a useful additive to foods, gels, and foams.

It’s long been used to improve the texture of food, and the earliest reported uses of red seaweed to improve a food’s characteristics dates back to 600 BC in China. It began to be used commercially in the west starting in the 1930′s, and about 80% of the world’s red seaweed is harvested in the philippines.

Uses

Carrageenan is cheap, fairly docile, and easy to crank out. So it’s used in a lot things. You’ll often see it in milk products to improve viscosity, especially plant milks since they don’t have any cream. Its others uses include but are not limited to:

• toothpaste
• gummy products
• dairy products/plant milks
• beer
• shoe polish
• shaving cream

And the list goes on. You’ll often see carrageenan used in conjunction with agar, guar gum, or xantham gum.

So Is Carrageenan Bad For You?

Carrageenan has always gotten a free pass from the health community. It’s frequently used as a vegan alternative to gelatin and recently herbivores have come to its defense because dairy companies have been framing it as a “weird additive” in its milk commercials.

Carrageenan helps make foods they like more palatable, and therefore they defend carrageenan as well.

I believe this sense of affiliation is incorrect.

Why, you ask?

Because carrageenan has a long and notable history of significant correlations to different types of cancer and acute-inflammatory responses which are not good for you, to say the least.

Inflammation

When searching Google for carrageenan one will be surprised to see that the most relevant, cited papers had little to do with carrageenan as a food additive, but instead focused on its ability to induce acute inflammation in rats.

We were surprised to find that by far the most notable aspect of carrageenan in medical research is its clockwork like ability to induce oedema and other inflammatory responses in rats. They’ve been doing it in labs for more than 40 years.

Carrageenan ingested in large amounts promotes inflation in two ways: it depresses the activity of macrophages (big immune cells that act like garbage collectors) and induces the creation of histamine, Cox-2 and prostaglandins, all inflammation inducing compounds.

Cancer

Regular ingestion of carrageenan also has a high correlation to different sorts of gastrointestinal cancers in rats. Most of the research done on the carrageenan/cancer relationship has been done in southeast Asia, and thus is not as well publicized as other harmful food additives like MSG.

However, the trail of research on this issue is long, and pretty consistent. Carrageenan (particularly the “degraded” kind) regularly induces carcinogenesis, neoplasia, and intestinal lesions. Ouch!

By far the most impressive research in this issue was carried out by a professor named Kazuo Wakabayashi, who’s centered in Japan.

Two relevant studies for you to chew on:

A clinical study conducted by Wakabayashi found that rodents were fed daily with a 5% carrageenan aqueous solution had a 100% incidence rate of colon metaplasis after 15 months.
As far as I know there have been no clinical studies conducted on humans, but they have been performed on mice, rabbits, guinea pigs, and mice and they all show a connection between carrageenan and colon cancer.
Food for thought.

So Is Carrageenan Safe?

Throughout most of the world carrageenan has been deemed “generally safe.” And in modest quantities it is, just like most other additives you consume in processed food.

Some people are miffed at the lack of attention its received for its potentially harmful side effects. The health community typically likes to throw stones at any and all preservatives added by the industrial process, and are quick to point out any harmful correlations that have been brought up in medical research. For example, the correlation between MSG and obesity has received a lot of scrutiny.

Why does carrageenan gets a free pass. It shouldn’t.

Research and References on Carrageenan
Vinegar, R, et. al “Quantitative Studies of the Pathway to Acute Carrageenan Inflammation” Federation Proceedings. 1976, pgs. 2447-2456.

URL: http://ukpmc.ac.uk/abstract/MED/976489

Di Rosa, M, et. al. “Studies of the Mediators of Acute Inflammatory Response Induced in Rats in Different Sites by Carrageenan and Turpentine” Journal of Pathology. May, 1971. Pgs 15-29.

URL:http://onlinelibrary.wiley.com/doi/10.1002/path.1711040103/abstract

Wakabayashi, Kazuo, et. al. “Induction by Degraded Carrageenan of Colorectal Tumors in Rats” Cancer Letters. January 1978, pgs. 171-176.

URL:http://www.sciencedirect.com/science/article/pii/S0304383578942374

Watanabe, Kenshi, et. al. “Effect of Dietary Undegraded Carrageenan on Colon Carcinogenesis in F344 Rats Treated With Azoxymethane or Methylnitrosurea” Cancer Research. December 1978, pgs. 4427-4430.

URL:http://cancerres.aacrjournals.org/content/38/12/4427.full.pdf

Tobacman, Joanne. “Review of Harmful Gastrointestinal Effects of Carrageenan in Animal Experiments” Environmental Health Perspectives. October 2001, pgs. 983-994.

URL:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1242073/pdf/ehp0109-000983.pdf

Guay, Jocelyne, et. al. “Carrageenan-Induced Paw Edema in Rat Elicits a Predominant Prostaglandin E2 Response in the Central Nervous System Associated with the Induction of Microsoma PGE2 Synthase-1″ Journal of Biological Chemistry. June 2004, pgs 24866-24872.

URL:http://www.jbc.org/content/279/23/24866.full.pdf+html

Salvemini, Daniela, et. al. “Nitric Oxide: A Key Mediator in the Early and Late Phase of Carrageenan-Induced Rat Paw Inflammation” British Journal of Pharmacology. Pgs 829-838.

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